Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial
Published: March 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/43467.13595
Deepak Premnarayan Gupta, Vijay Chandak
1. Junior Resident, Department of Anaesthesia, DMIMS, Sawangi, Wardha, Maharashtra, India.
2. Associate Professor, Department of Anaesthesia, DMIMS, Sawangi, Wardha, Maharashtra, India.
Correspondence
Dr. Deepak Premnarayan Gupta,
Junior Resident, Department of Anaesthesia, DMIMS, Wardha-442004, Maharashtra, India.
E-mail: deardeepu2589@gmail.com
Introduction: Postoperative Nausea and Vomiting (PONV) is a common entity following surgical procedure. It may result into serious complication like aspiration of gastric contents, prolonged recovery period. Palonosetron is a selective serotonin antagonist that is 5HT3 receptor antagonist with little to no affinity for other receptors and has a longer duration of action. Ondansetron is also a 5HT3 receptor antagonist with shorter duration of action and some side effects.
Aim: To compare the effectiveness of ondansetron and palonosetron for the prevention of PONV following upper abdominal surgeries.
Materials and Methods: This prospective single-blind study included 120 patients randomly assigned to the palonosetron group (n=60) or the ondansetron group (n=60). Using the chi-square test and calculating p-value, the two groups were compared.
Results: The incidence of nausea, vomiting and use of rescue antiemetic was significantly less in palonosetron group as compared to ondansetron group.
Conclusion: From the study, it can be concluded that palonosetron at a dose of 0.075 mg is safe, with lesser side effects and proved more effective than ondansetron 4 mg in prevention of PONV.
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